I am not sure I would ever stop using PriceLine for booking hotels, but I found a great website with great deals! Check out www.getaroom.com ! If you need to find a great rate for a specific hotel, I would definitely check this one out.
Some other favorites are:
and of course - www.priceline.com
Always look for last minute deals! Even if you have your flight booked, wait to book your hotel till the week before... The hotel does not want to be empty and would rather give you a lower rate than have a room sit empty.